The CETICS TOXXs Analyzer determines the DNA-damaging impact of radiation and genotoxic substances in mammalian cells with the automated FADU Assay ('Fluorimetric detection of Alkaline DNA Unwinding’). Additionally, even after short exposure times, the FADU Assay permits the determination of the individual DNA repair capacities of cells. The differentiation of both effects is important for the reliable evaluation of genotoxic potential of the test substances.
The automated FADU Assay is significantly faster and simpler to handle than established genotoxicity tests such as the COMET Assay. Its application can make a significant contribution to avoiding animal experiments.
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